Premium
Osteocyte RANKL: New insights into the control of bone remodeling
Author(s) -
Xiong Jinhu,
O'Brien Charles A
Publication year - 2012
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.1547
Subject(s) - rankl , osteoclast , osteocyte , bone remodeling , progenitor cell , microbiology and biotechnology , osteoblast , cancellous bone , activator (genetics) , receptor , chemistry , biology , medicine , endocrinology , stem cell , pathology , biochemistry , in vitro
The idea that osteoblasts, or their progenitors, support osteoclast formation by expressing the cytokine receptor activator of NFkB ligand (RANKL) is a widely held tenet of skeletal biology. Two recent studies provide evidence that osteocytes, and not osteoblasts or their progenitors, are the major source of RANKL driving osteoclast formation in cancellous bone. The goal of this review is to highlight the results of these new studies and discuss their implications for our understanding of bone remodeling. © 2012 American Society for Bone and Mineral Research