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Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: Results from the look AHEAD randomized trial
Author(s) -
Schwartz Ann V,
Johnson Karen C,
Kahn Steven E,
Shepherd John A,
Nevitt Michael C,
Peters Anne L,
Walkup Michael P,
Hodges Amelia,
Williams Carrie C,
Bray George A
Publication year - 2012
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.1483
Subject(s) - medicine , bone mineral , overweight , femoral neck , weight loss , glycemic , type 2 diabetes , diabetes mellitus , body mass index , bone density , randomized controlled trial , osteopenia , obesity , osteoporosis , physical therapy , surgery , endocrinology
Intentional weight loss is an important component of treatment for overweight patients with type 2 diabetes, but the effects on bone density are not known. We used data from the Look AHEAD trial to determine the impact of an intensive lifestyle weight loss intervention (ILI) compared with diabetes support and education (DSE) on changes in bone mineral density (BMD) over 12 months. Overweight and obese adults with type 2 diabetes were randomly assigned to ILI or DSE. In a substudy of BMD conducted at 5 of 16 clinical centers, hip, spine, and whole body dual X‐ray absorptiometry scans were obtained at baseline and 1‐year later on 642 of 739 ILI and 632 of 740 DSE participants. At baseline, mean age was 58.4 years, and average body mass index was 35.2 kg/m 2 . Total hip BMD T ‐score was <−2.5 in 1% and <−1.0 in 8%. At 1 year, weight loss was greater in ILI than DSE (−8.6% versus −0.7%), and glycemic control and fitness were also improved. Bone loss over 1 year was greater in ILI at the total hip (−1.4% versus −0.4%; p < 0.001) and femoral neck (−1.5% versus −0.8%; p = 0.009), but change in BMD for the lumbar spine and whole body did not differ between groups. In ILI, bone loss at the total hip was independently associated with weight loss in men and women and with poorer glycemic control in men, but was not associated with changes in fitness. One year of an intensive lifestyle intervention in adults with type 2 diabetes, resulting in weight loss, was associated with a modest increase in hip bone loss despite improved fitness and glycemic control. © 2012 American Society for Bone and Mineral Research