Open AccessChronobiology and Chronotherapy of Osteoporosis
Author(s) -
Winter Elizabeth M,
Kooijman Sander,
AppelmanDijkstra Natasha M,
Meijer Onno C,
Rensen Patrick CN,
Schilperoort Maaike
Publication year - 2021
Publication title -
jbmr plus
Language(s) - English
Resource type - Journals
ISSN - 2473-4039
DOI - 10.1002/jbm4.10504
Subject(s) - chronotherapy (sleep phase) , circadian rhythm , osteoporosis , bone remodeling , clock , chronobiology , circadian clock , biology , senile osteoporosis , medicine , bioinformatics , neuroscience , endocrinology
Physiological circadian (ie, 24‐hour) rhythms are critical for bone health. Animal studies have shown that genes involved in the intrinsic molecular clock demonstrate potent circadian expression patterns in bone and that genetic disruption of these clock genes results in a disturbed bone structure and quality. More importantly, circulating markers of bone remodeling show diurnal variation in mice as well as humans, and circadian disruption by, eg, working night shifts is associated with the bone remodeling disorder osteoporosis. In this review, we provide an overview of the current literature on rhythmic bone remodeling and its underlying mechanisms and identify critical knowledge gaps. In addition, we discuss novel (chrono)therapeutic strategies to reduce osteoporosis by utilizing our knowledge on circadian regulation of bone. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.