Open AccessInteractions of Phosphate Metabolism With Serious Injury, Including Burns
Author(s) -
Porter Craig,
Sousse Linda E,
Irick Ryan,
Schryver Eric,
Klein Gordon L
Publication year - 2017
Publication title -
jbmr plus
Language(s) - English
Resource type - Journals
ISSN - 2473-4039
DOI - 10.1002/jbm4.10011
Subject(s) - phosphate , parathyroid hormone , high energy phosphate , adenosine triphosphate , metabolism , energy metabolism , chemistry , endocrinology , medicine , biochemistry , calcium , phosphocreatine
Approximately 85% of the body's phosphate pool resides within the skeleton. The remaining 15% is stored as high‐energy phosphates or in its free form, where it acts as a substrate for adenosine triphosphate (ATP) production. Accordingly, phosphate plays a crucial role in energy metabolism. Trauma and critical illness result in a hypermetabolic state in which energy expenditure increases. The impact of trauma and critical illness on the body's phosphate stores and phosphate‐dependent metabolic reactions is poorly understood. We had previously observed that after severe burn trauma, increased energy expenditure is temporally related to a marked reduction in serum concentrations of both parathyroid hormone and fibroblast growth factor 23, both of which have phosphaturic effects. The aim of this article is to describe as far as is known the similarities and differences in phosphate metabolism in different types of injury and to infer what these differences tell us about possible signaling pathways that may link increased phosphate utilization and phosphate retention. © 2017 The Authors. JBMR Plus is published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.