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Poly (γ‐glutamic acid)/chitooligo‐saccharide/papain hydrogel prevents hypertrophic scar during skin wound healing
Author(s) -
Xue Yueming,
Qi Chunxiao,
Dong Yunsheng,
Zhang Lin,
Liu Xiangsheng,
Liu Yufei,
Wang Shufang
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34830
Subject(s) - hypertrophic scar , wound healing , scars , in vivo , regeneration (biology) , papain , self healing hydrogels , adhesion , chemistry , biomedical engineering , medicine , surgery , microbiology and biotechnology , biochemistry , biology , enzyme , organic chemistry
Hypertrophic scar, a common skin disorder typically caused by deep burns or scald were usually treated via surgical resection, laser irradiation, and drugs. However, all the approaches were always companied with complications and devastatingly subjected to relapse, which indicated the urgently need of an effective treatment method. In this project, a new hydrogel composed of Poly (γ‐glutamic acid) (γ‐PGA), Chitooligo‐saccharide, and Papain was developed via crosslinker (EDC&NHS), and characterized with good porously three‐dimensional network structure, good water absorption, and mechanical properties. Besides, G/C/P hydrogel facilitated cell adhesion and inhibited excessive proliferation of fibroblasts, which indicated the potential of in vivo application. After applied onto skin wound healing in vivo on a rabbit ear skin wound model, G/C/P hydrogel inhibited excessive collagen deposition and the generation of hyperplastic scars effectively during wound healing. The hydrogel described here provide a new platform for regeneration field and hold great promise for solving serious skin disorder.