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Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4 : Eu3@ poly (levodopa) luminescent nanoparticles
Author(s) -
HashemiMoghaddam Hamid,
Ebrahimi Mansore,
Johari Behrooz,
Madanchi Hamid
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34816
Subject(s) - paclitaxel , in vivo , luminescence , nanoparticle , surface modification , materials science , drug delivery , biophysics , peptide , chemistry , nanotechnology , cancer , biochemistry , medicine , optoelectronics , microbiology and biotechnology , biology
Targeted drug delivery enhances drug efficiency and selectivity without affecting normal cells. Luminescent nanoparticles can be used for tumor imaging as well as selective tumor targeting for drug delivery. In this research, LaVO 4 :Eu 3+ was synthesized, the luminescent nanocrystal was coated by surface polymerization of levodopa in the presence of Paclitaxel (PTX), and then NL2 peptide was coupled on the surface of polymer‐coated luminescent nanoparticles. Next, the capability of the modified drug was examined by in vitro and in vivo experiments. MTT assay on SK‐BR‐3 cell line (as breast cancer cells) and fluorescent microscopy results indicate that this modification decreases significantly drug toxicity and increases its selectivity. In addition, in vivo experiments confirm more capability of the NL2‐functionalized nanocomposite for reducing tumor size, drug distribution in the body, and more aggregation of PTX in tumor tissue. Overall, it is concluded that tumor imaging is possible using luminescent LaVO 4 :Eu 3+ core and NL2 peptide increases significantly the specificity of PTX in combination with a functionalized luminescent polymeric carrier.