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Effect of cetyltrimethyl‐ammonium bromide on the properties of hydroxyapatite nanoparticles stabilized Pickering emulsion and its cured poly(L‐lactic acid) materials
Author(s) -
Zhu Zhuo,
Wang Aijuan,
Xue Hua,
Liu Rong,
Miao Luyang,
Liu Dongjie,
Song Yang
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34814
Subject(s) - pickering emulsion , ammonium bromide , emulsion , zeta potential , chemical engineering , nanoparticle , materials science , aqueous two phase system , contact angle , scanning electron microscope , porosity , phase inversion , lactic acid , phase (matter) , pulmonary surfactant , chemistry , composite material , nanotechnology , organic chemistry , membrane , biochemistry , biology , bacteria , engineering , genetics
Hydroxyapatite (HAp) nanoparticles stabilized Pickering emulsions were prepared by dichloromethane (CH 2 Cl 2 ) dissolved poly(L‐lactic acid) (PLLA) as the oil phase and the deionized water with different concentrations of cetyltrimethyl‐ammonium bromide (CTAB) as the aqueous phase. Effect of CTAB concentration on emulsions type and stability were studied. The emulsion type underwent a two‐phase inversion, and emulsion stability increased first and then decreased with increasing CTAB concentrations. Besides, effect of CTAB concentration on zeta potential, aggregate size, contact angle of HAp nanoparticles and the oil–water interfacial tension were studied. The results indicated that zeta potential value of HAp nanoparticles changed from negative to positive, and the contact angle increased to over 80° initially and then decreased to below 40° rapidly. The distribution of HAp nanoparticles on the surface of emulsion droplets with different concentrations of CTAB (5 and 20 mM) was characterized using laser‐induced confocal microscope. It revealed the distribution of HAp nanoparticles changed with different CTAB concentrations. The cured PLLA materials were obtained after the solvent being volatilized using as‐received emulsions as templates. Scanning electron microscope images showed both microspheres and porous materials with interconnected pore structure were obtained. In conclusion, the microstructure of microspheres or porous PLLA materials is controllable by adjusting the property of HAp nanoparticles stabilized Pickering emulsions with appropriate amount of CTAB.