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Fabrication and characterization of electrospun biopolyester/gelatin nanofibers
Author(s) -
Ulker Turan Cansu,
Guvenilir Yuksel
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34807
Subject(s) - gelatin , electrospinning , nanofiber , glutaraldehyde , materials science , membrane , chemical engineering , polymer , fabrication , wetting , contact angle , drug delivery , polymer chemistry , nanotechnology , composite material , chromatography , organic chemistry , chemistry , medicine , biochemistry , alternative medicine , pathology , engineering
Poly(ω‐pentadecalactone‐ co ‐ε‐caprolactone) copolymer (PDL‐CL) is an enzymatically synthesized aliphatic biopolyester, which has been participated in a nanofibrous structure for the first time. Electrospinning of this synthetic polymer by blending with a natural polymer such as gelatin (Gel) could provide new characteristics that are significant for biomedical applications, such as drug delivery, wound healing, and tissue engineering. In the present study, PDL‐CL/Gel nanofibrous membranes were successfully produced and characterized. The average diameter of nanofibers was 305.0 ± 45.5 nm that may be beneficial in applications mentioned above. In order to increase hydrolytic resistance, cross‐linking with glutaraldehyde vapor was applied. Cross‐linking for 2 h was enough to obtain a nanofibrous membrane that was able to resist in pH 7.4 phosphate buffered saline for 30 days. In addition, contact angle measurement results had shown that, cross‐linked nanofibrous membrane had good wettability, which is a required specification to be applied in biomedical field. Hence, this study provides an overview on fabrication of fine PDL‐CL/Gel nanofibers, which may have potential to be used in biomedical area.