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Inhibition of oral biofilm formation by zwitterionic nonfouling coating
Author(s) -
Sun Fang,
Hung HsiangChieh,
Yan Weishi,
Wu Kan,
Shimchuk Andy A.,
Gray Sterling D.,
He Wei,
Huang Xuelian,
Zhang Hai
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34801
Subject(s) - biofilm , coating , contact angle , protein adsorption , chemistry , enamel paint , adhesion , adsorption , polymer , chemical engineering , streptococcus mutans , materials science , polymer chemistry , bacteria , organic chemistry , composite material , genetics , engineering , biology
Inhibition of oral biofilm formation is critical to prevent and treat dental caries and periodontal diseases. In this study, we synthesized zwitterionic poly(carboxybetaine) (pCB) based polymer as a nonfouling coating to provide anti‐bacterial properties to tooth surfaces. Four catechol derived l ‐3,4‐dihydroxyphenylalanine (DOPA) groups were conjugated to pCB to serve as a surface anchoring group. The pCB‐(DOPA) 4 polymer was coated on the hydroxyapatite (HA) and enamel samples by simple immersion and characterized by Raman spectroscopy. The nonfouling effectiveness of the pCB based coating was determined by protein adsorption and bacterial adhesion assays. The coating was transparent on sample surfaces. The protein adsorption was significantly reduced to 8.2% and 6.9%, respectively, on pCB‐(DOPA) 4 coated HA and enamel samples. The pCB‐(DOPA) 4 ‐coated samples also demonstrated significantly fewer adhered Pseudomonas aeruginosa , Staphylococcus aureus , and Streptococcus mutants compared to the control. This novel coating material provides an innovative approach to resist biofilm formation on tooth surfaces and has great potential in future dental clinical applications.