Premium
Preparation of PEG ‐modified wool keratin/sodium alginate porous scaffolds with elasticity recovery and good biocompatibility
Author(s) -
Ji Ji,
Chen Guang,
Liu Zitong,
Li Lili,
Yuan Jiugang,
Wang Ping,
Xu Bo,
Fan Xuerong
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34791
Subject(s) - porosity , keratin , biocompatibility , scaffold , chemical engineering , materials science , tissue engineering , chemistry , composite material , biomedical engineering , pathology , engineering , medicine
To improve mechanical properties of keratin (KR) porous scaffolds, we prepared a PEGylated keratin through thiol‐ene click reaction. Several porous scaffolds were prepared by blending PEGylated keratin with sodium alginate (SA). The surface morphology, mechanical properties, and porosity of scaffolds were detailed studied at different KR/SA proportions. The results showed the content of SA had an effect on pore formation and mechanical properties. When the mass ratio of KR to SA was 2:1, the stress of yield point of the keratin porous scaffold reached 1.24 MPa, and also showed good deformation recovery ability. The PEGylated keratin porous scaffold had a high porosity and great cytocompatibility. Its' porosity is up to 81.7% and the cell viability is about 117.78%. This allows it to absorb the simulated plasma quickly (9.20 ± 0.37 g/g). In addition, the structural stability and acid–base stability of the keratin porous scaffold were also improved after PEGylation. Overall, the PEGylated keratin porous scaffold will be promising in tissue materials due to its great physical, chemical, and biological properties.