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Human Amniotic Membrane: A review on tissue engineering, application, and storage
Author(s) -
LealMarin Sara,
Kern Thomas,
Hofmann Nicola,
Pogozhykh Olena,
Framme Carsten,
Börgel Martin,
Figueiredo Constanca,
Glasmacher Birgit,
Gryshkov Oleksandr
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34782
Subject(s) - tissue engineering , extracellular matrix , wound healing , scaffold , angiogenesis , regeneration (biology) , decellularization , biomedical engineering , tissue repair , microbiology and biotechnology , biology , medicine , surgery , cancer research
Abstract Human amniotic membrane (hAM) has been employed as scaffolding material in a wide range of tissue engineering applications, especially as a skin dressing and as a graft for corneal treatment, due to the structure of the extracellular matrix and excellent biological properties that enhance both wound healing and tissue regeneration. This review highlights recent work and current knowledge on the application of native hAM, and/or production of hAM‐based tissue‐engineered products to create scaffolds mimicking the structure of the native membrane to enhance the hAM performance. Moreover, an overview is presented on the available (cryo) preservation techniques for storage of native hAM and tissue‐engineered products that are necessary to maintain biological functions such as angiogenesis, anti‐inflammation, antifibrotic and antibacterial activity.