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Low‐shrinkage‐stress nanocomposite: An insight into shrinkage stress, antibacterial, and ion release properties
Author(s) -
Bhadila Ghalia,
Wang Xiaohong,
Weir Michael D.,
Melo Mary Ann S.,
Martinho Frederico,
Fay Guadalupe Garcia,
Oates Thomas W.,
Sun Jirun,
Xu Hockin H. K.
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34775
Subject(s) - shrinkage , amorphous calcium phosphate , nanocomposite , materials science , composite number , biofilm , composite material , nuclear chemistry , chemistry , calcium , bacteria , biology , metallurgy , genetics
The aims are: (a) To develop the first low‐shrinkage‐stress nanocomposite with antibacterial and remineralization capabilities through the incorporation of dimethylaminododecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP); (b) to investigate the effects of the new composite on biofilm inhibition, mechanical properties, shrinkage stress, and calcium (Ca) and phosphate (P) ion releases. The low‐shrinkage‐stress resin consisted of urethane dimethacrylate and triethylene glycol divinylbenzyl ether. Composite was formulated with 3% DMAHDM and 20% NACP. Mechanical properties, shrinkage stress, and degree of conversion were evaluated. Streptococcus mutans biofilm growth on composites was assessed. Ca and P ion releases were measured. The shrinkage stress of the low‐shrinkage‐stress composite containing 3% DMAHDM and 20% NACP was 36% lower than that of traditional composite control ( p < 0.05), with similar degrees of conversion of 73.9%. The new composite decreased the biofilm colony‐forming unit by 4 log orders and substantially reduced biofilm lactic acid production compared to control composite ( p < 0.05). Incorporating DMAHDM to the low‐shrinkage‐stress composite did not adversely affect the Ca and P ion release. A novel bioactive nanocomposite was developed with low shrinkage stress, strong antibiofilm activity, and high levels of ion release for remineralization, without undermining the mechanical properties and degree of conversion.