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Fabrication of bioactive novel scaffold by solid‐state reaction sintering for bone regeneration
Author(s) -
López Erika,
Viatela Yrina,
Prado Miguel,
Biolatti Vanesa,
Bagnatto Carolina
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34770
Subject(s) - sintering , chemical engineering , dissolution , porosity , materials science , simulated body fluid , scaffold , calcium silicate , calcium , phosphate , chemistry , mineralogy , composite material , scanning electron microscope , biomedical engineering , organic chemistry , metallurgy , medicine , engineering
In this work we present a new type of scaffold obtained by solid‐state reaction, simultaneous sintering of a mixture of precursor oxides, carbonates, and organic substances, the latter used for pore generation. Having variable local composition, exhibits excellent overall physicochemical and bioactivity response. Open porosity is about 50%–60% and its permeability 10 −11 m 2 . X‐ray diffraction exhibits the presence of a sodium‐calcium silicate and sodium‐calcium phosphate crystalline phases. Additionally, by mechanical compression tests the range of failure stress obtained for the scaffolds was 0.3–1.1 MPa. The bioactivity and dissolution rate of the scaffolds were evaluated by in vitro tests. After 1 week soaking in simulated body fluid, the formation of a continuous hydroxyapatite layer, which does not differentiate local compositions, was observed. Our results from cell culture tests clearly indicate that during hydroxyapatite layer formation, scaffolds do not liberate any cytotoxic substances. Moreover, cells seeded in the hydroxyapatite‐covered scaffolds grew better than the control.