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A multifunctional dual‐shell magnetic nanocomposite with near‐infrared light response for synergistic chemo‐thermal tumor therapy
Author(s) -
Li Sheng,
Shi Xiaowen,
Wang Haibo,
Xiao Ling
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34749
Subject(s) - nanocages , in vivo , photothermal therapy , nanocomposite , nanotechnology , materials science , nanoparticle , magnetic resonance imaging , chemistry , medicine , organic chemistry , microbiology and biotechnology , radiology , biology , catalysis
Abstract The synergistic tumor therapy in single nanoplatform has always been the goal for high efficacy tumor treatment while still remains great challenge. This paper reports a versatile nanotheranostic platform enlisting magnetic iron oxide nanoparticles, polydopamine (PDA), gold nanocages (Au nanocage) and metal organic framework (MOF, MIL101‐NH 2 ) in order to achieve synergistic chemothermal tumor therapy both in vitro and in vivo. The prepared magnetic photothermal nanoparticles (MPNPs) exhibit high drug loading capacity (31.34 mg/g), superior photo‐thermal capacity (11.5°C enhancement in 180 s), low bio‐toxicity, good magnetic resonance with a low dosage of 22 μg/g, as well as high antitumor efficacy in vivo. Such a novel and multifunctional nanoplatform is expected to find promising applications in target tumor synergistic therapy.