Premium
Polyether ether ketone surface modification with plasma and gelatin for enhancing cell attachment
Author(s) -
Mehdizadeh Omrani Maryam,
Kumar Hitendra,
Mohamed Mohamed G. A.,
Golovin Kevin,
S. Milani Abbas,
Hadjizadeh Afra,
Kim Keekyoung
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34726
Subject(s) - peek , materials science , biocompatibility , wetting , gelatin , surface modification , surface roughness , polyether ether ketone , contact angle , scanning electron microscope , adhesion , composite material , biomedical engineering , chemical engineering , chemistry , organic chemistry , polymer , medicine , engineering , metallurgy
Polyether ether ketone (PEEK) has shown great promise for implant and biomedical applications because of its excellent chemical, mechanical, and biocompatible properties. However, PEEK is bioinert, which causes weak cell adhesion and limits its use for biomedical applications such as bone implants. Therefore, the activation of the PEEK's surface for cell attachment is desirable. In this study, oxygen plasma and gelatin were used to modify PEEK's surface and the effects of surface roughness, wettability, and cell adhesion to the surface were studied. Surface roughness was measured using a laser scanning confocal microscope, and wettability was measured using the sessile drop method. There was no significant difference in the roughness of the three samples. The gelatin‐coated surface showed higher wettability than the plasma‐modified or control samples. The cell attachment and proliferation rate were assessed by scanning electron microscopy and the XTT assay, respectively. The XTT assay results indicated that a greater number of cells grew on the gelatin‐coated PEEK surface than on the control or plasma‐treated surfaces. These results confirmed that the plasma and gelatin treatments enhanced the biocompatibility of the PEEK samples. The increase in biocompatibility could make PEEK a better material candidate for treating bone related injuries and defects.