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Fe/Mn multilayer nanowires as dual mode T 1 – T 2 magnetic resonance imaging contrast agents
Author(s) -
Gu Liyuan,
Cao Xiaoming,
Mukhtar Aiman,
Wu KaiMing
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34715
Subject(s) - materials science , nanowire , nuclear magnetic resonance , analytical chemistry (journal) , magnetic resonance imaging , resonance (particle physics) , magnetometer , scanning electron microscope , transmission electron microscopy , nanotechnology , chemistry , magnetic field , medicine , physics , chromatography , particle physics , quantum mechanics , composite material , radiology
To overcome the negative contrast limitations, and to improve the sensitivity of the magnetic resonance signals, the mesoporous silica coated Fe/Mn multilayered nanowires (NWs) were used as a T 1 –T 2 dual‐mode contrast agents (CAs). The single component Fe and Mn NWs, and Fe/Mn multilayer NWs were synthesized by electrodeposition in the homemade anodic aluminum oxide (AAO) templates with the aperture of about 30 nm. The structural characterization and morphology of single component and multisegmented NWs was done by X‐ray diffraction and transmission electron microscopy. The elemental composition of Fe/Mn multilayerd NWs was confirmed by energy‐dispersive X‐ray and energy‐dispersive spectrometer. Vibrating sample magnetometer was used to test the magnetic properties, and 1.5 T magnetic resonance imaging (MRI) scanner was used to measure the relaxation efficiency. Importantly, the MRI study indicated that the Fe/Mn multilayer NWs showed a significant T 1 –T 2 imaging effect, and have longitudinal relaxivity (r 1 ) value, that is, 1.25 ± 0.0329 × 10 −4 μM −1 s −1 and transverse relaxivity (r 2 ), that is, 5.13 ± 0.123 × 10 −4 μM −1 s −1 , which was two times of r 1 value (0.654 ± 0.00899 × 10 −4 μM −1 s −1 ) of Mn NWs, and r 2 value (2.96 ± 0.0415 × 10 −4 μM −1 s −1 ) of Fe NWs. Hence, Fe/Mn multilayer NWs have potential to be used as T 1 –T 2 dual‐mode CAs.