Premium
Combination of biocompatible hydrogel precursors to apatitic calcium phosphate cements ( CPCs ): Influence of the in situ hydrogel reticulation on the CPC properties
Author(s) -
Ramirez Caballero Silvia Stella,
FerriAngulo Daniel,
Debret Romain,
Granier Fabien,
Marie Sébastien,
Lefèvre FrançoisXavier,
Bouler JeanMichel,
Despas Christelle,
Sohier Jérôme,
Bujoli Bruno
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34685
Subject(s) - polymer , microstructure , materials science , apatite , composite number , chemical engineering , porosity , biocompatibility , self healing hydrogels , chemistry , composite material , polymer chemistry , mineralogy , engineering , metallurgy
In the field of bone regenerative medicine, injectable calcium phosphate cements (CPCs) are used for decades in clinics, as bone void fillers. Most often preformed polymers (e.g., hyaluronic acid, collagen, chitosan, cellulose ethers…) are introduced in the CPC formulation to make it injectable and improve its cohesion. Once the cement has hardened, the polymer is simply trapped in the CPC structure and no organic subnetwork is present. By contrast, in this work a CPC was combined with organic monomers that reticulated in situ so that a continuous biocompatible 3D polymeric subnetwork was formed in the CPC microstructure, resulting in a higher permeability of the CPC, which might allow to accelerate its in vivo degradation. Two options were investigated depending on whether the polymer was formed before the apatitic inorganic network or concomitantly. In the former case, conditions were found to reach a suitable rheology for easy injection of the composite. In addition, the in situ formed polymer was shown to strongly affect the size, density, and arrangement of the apatite crystals formed during the setting reaction, thereby offering an original route to modulate the microstructure and porosity of apatitic cements.