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A convenient approach by using poly‐( HEMA‐co‐NIPAM )/Cu 2+ solution sol–gel transition for wound protection and healing
Author(s) -
Wang Yansong,
Chu Xin,
Sun Yu,
Teng Peng,
Xia Tianzhi,
Chen Yisheng
Publication year - 2021
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34679
Subject(s) - wound healing , aqueous solution , in vivo , angiogenesis , wound closure , wound dressing , polymerization , polymer , surgery , materials science , biomedical engineering , chemistry , polymer chemistry , medicine , organic chemistry , composite material , cancer research , biology , microbiology and biotechnology
Rapid and convenient wound healing is crucial for reducing potential post‐traumatic wound complications. In this study, a temperature‐sensitive polymer of poly‐(HEMA‐co‐NIPAM) (PHN) was synthesized by free‐radical polymerization, in which the solution quickly underwent a sol–gel transition above 29°C, thus responding to a typical body temperature and facilitating wound sealing. PHN solution incorporated with copper ions (PHN‐Cu) not only exhibited excellent antibacterial properties, but also expedited wound closure and facilitated tissue angiogenesis. The in vivo and in vitro experiments showed that the PHN‐Cu had a higher wound closure rate and demonstrated an ability to promote skin tissue angiogenesis. Such a versatile, convenient aqueous solution could enable nonprofessionals to promptly treat wounds in a short time after injury, thus providing suitable conditions for later treatment, and can be used as a convenient method to clean wounds.