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Application of a novel thermo‐sensitive injectable hydrogel in therapy in situ for drug accurate controlled release
Author(s) -
Kong Xiaoying,
Houzong Ruizhi,
Fu Jun,
Shao Kai,
Wang Lili,
Ma Yongchao,
Shi Jinsheng
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34658
Subject(s) - self healing hydrogels , drug , drug delivery , in vivo , chitosan , biomedical engineering , controlled release , pharmacology , chemistry , materials science , nanotechnology , medicine , biochemistry , polymer chemistry , microbiology and biotechnology , biology
Local drug injection therapy for tumor site, as a neoadjuvant chemotherapy method, shows important significance in clinical application; however, it obtains unsatisfying therapeutic effect due to the serious toxic and side effect in normal tissues caused by drug diffusion or complexity of the preparation. In this article, the influence factors of the gelling time of traditional Chitosan (CTS) thermo‐sensitive hydrogels were analyzed, and the gelling properties were improved significantly, and a thermo‐sensitive hydrogel with precisely regulated gelling time was obtained through a green and simple preparation method, and the shortest gelling time (gelling time = 27 ± 2 s) of this hydrogel was 5% of that of the common CTS thermo‐sensitive hydrogels. After loaded with different chemotherapy drugs with different pH values (gemctiabin hydrochloride, levofloxacin, and 5‐foluorouracil), the hydrogels' gelling performance was not affected, while the gelling time could be shortened by 5‐foluorouracil, effectively hindering the drug loss at the early stage of sustained release. in vitro and in vivo experiments proved that precise encapsulation toward tumors with different volumes was achieved by the hydrogels, with minimal damage to surrounding normal tissues and higher utilization of drugs in tumor sites, ultimately achieving better tumor therapeutic effect. In conclusion, the new thermo‐sensitive hydrogels with precisely regulated gelling time showed great significance and potential for drug delivery and neoadjuvant chemotherapy.