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Crosslinking of gum‐based composite scaffolds for enhanced strength and stability: A comparative study between sodium trimetaphosphate and glutaraldehyde
Author(s) -
Joglekar Mugdha Makrand,
Ghosh Devlina,
Anandan Dhivyaa,
Yatham Puja,
Jayant Rahul Dev,
Nambiraj N. Arunai,
Jaiswal Amit Kumar
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34640
Subject(s) - glutaraldehyde , xanthan gum , biocompatibility , materials science , polyvinyl alcohol , gellan gum , tissue engineering , chemical engineering , drug delivery , compressive strength , biodegradation , swelling , fourier transform infrared spectroscopy , composite number , biomedical engineering , composite material , chemistry , nanotechnology , organic chemistry , engineering , medicine , food science , rheology , metallurgy
Tissue engineering is one of the potential fields in the domain of regenerative medicine. Engineered scaffolds are an excellent substitute for the conventional use of bone grafts as they are biocompatible, economic, and provide limitless supply with no risk of disease transmission. Gum‐based scaffolds present a good scope for studying tissue‐engineering models and analyzing controlled drug delivery. Uniform blending of the gums and the presence of the optimal concentration of appropriate crosslinkers are very crucial for biodegradability nature. Gum‐based scaffolds containing gellan gum, xanthan gum, polyvinyl alcohol, and hydroxyapatite, cross‐linked with either glutaraldehyde (GA) or sodium trimetaphosphate (STMP) were fabricated to study the efficiency of crosslinkers and were characterized for degradation profile, swelling capacity, porosity, mechanical strength, morphology, X‐ray diffraction, Fourier‐transform infrared, and in vitro biocompatibility. Scaffolds crosslinked with STMP exhibited higher degradation rate at Day 21 than scaffolds crosslinked with GA. However, higher compressive strength was obtained for scaffolds cross‐linked with STMP signifying that they have a better ability to resist compressive forces. Superior cell viability was observed in STMP‐crosslinked scaffolds. In conclusion, STMP serves as a better crosslinker in comparison to GA and can be used in the fabrication of scaffolds for bone tissue engineering.