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Functionalization of PEO layer formed on Ti‐15Mo for biomedical application
Author(s) -
Leśniak Katarzyna,
Płonka Joanna,
ŚmigaMatuszowicz Monika,
BrzychczyWłoch Monika,
KazekKęsik Alicja
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34504
Subject(s) - materials science , surface modification , staphylococcus epidermidis , scanning electron microscope , coating , cefazolin , nuclear chemistry , chemical engineering , chromatography , staphylococcus aureus , composite material , microbiology and biotechnology , bacteria , antibiotics , biology , chemistry , engineering , genetics
In the present work, deposition of poly(sebacic anhydride) PSBA loaded by amoxicillin, cefazolin, or vancomycin on a previously anodized Ti‐15Mo surface is presented. PSBA loaded by the drug was deposited so as not to lose the functionality of the porous oxide layer microstructure. The morphology was evaluated using scanning electron microscopy, surface roughness, and wettability. The drug concentration was evaluated using high‐performance liquid chromatography. It was determined that the drugs were loaded into coatings in the range of 35.2–122.87 μg/cm 2 of Ti sample. The drugs released more than 16% after 0.5 hr of the hybrid coating immersion in artificial saliva. After 3 days, the PSBA coatings were degraded by 51.3 mol %, and after 7 days by 77.8 mol %, which makes it possible to load the material by different, biologically active substances. An antimicrobial investigation of Staphylococcus aureus (DSM 24167) and Staphylococcus epidermidis (ATCC 700296) confirmed the activity of the hybrid layers against the pathogens. Hybrid layer with vancomycin best inhibits the adhesion of the bacteria, whereas coatings with amoxicillin and cefazolin showed a much better bactericidal activity. In this article, the difference in the obtained results is discussed, as well as the possibility of the application of this functional material in biomedicine.