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Fabrication of electrospun poly(lactic acid) nanoporous membrane loaded with niobium pentoxide nanoparticles as a potential scaffold for biomaterial applications
Author(s) -
Marins Natália H.,
Silva Ricardo M.,
Ferrua Camila P.,
Łukowiec Dariusz,
Barbosa Ananda M.,
Ribeiro Juliana S.,
Nedel Fernanda,
Zavareze Elessandra R.,
Tański Tomasz,
Carreño Neftalí L. V.
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34503
Subject(s) - materials science , biomaterial , membrane , nanoporous , niobium pentoxide , nanoparticle , tissue engineering , biocompatibility , chemical engineering , electrospinning , nanotechnology , biomedical engineering , polymer , composite material , niobium , chemistry , medicine , biochemistry , engineering , metallurgy
Tissue engineering aims to regenerate and restore damaged human organs and tissues using scaffolds that can mimic the native tissues. The requirement for modern and efficient biomaterials that are capable of accelerating the healing process has been considerably increased. In this work, a novel electrospun poly(lactic acid) (PLA) nanoporous membrane incorporated with niobium pentoxide nanoparticles (Nb 2 O 5 ) for biomaterial applications was developed. Nb 2 O 5 nanoparticles were obtained by microwave‐assisted hydrothermal synthesis, and different concentrations (0, 1, 3, and 5% wt/wt) were tested. Chemical, morphological, mechanical, and biological properties of membranes were evaluated. Cell viability results demonstrated that the membranes presented nontoxic effects. The incorporation of Nb 2 O 5 improved cell proliferation without impairing the wettability, porosity, and mechanical properties of membranes. Membranes containing Nb 2 O 5 nanoparticles presented biocompatible properties with suitable porosity, which facilitated cell attachment and proliferation while allowing diffusion of oxygen and nutrients. This study has demonstrated that Nb 2 O 5 nanoparticle‐loaded electrospun PLA nanoporous membranes are potential candidates for drug delivery and wound dressing applications.