Premium
Titania nanotube morphologies for osseointegration via models of in vitro osseointegrative potential and in vivo intramedullary fixation
Author(s) -
Baker Erin A.,
Vara Alexander D.,
Salisbury Meagan R.,
Fleischer Mackenzie M.,
Baker Kevin C.,
Fortin Paul T.,
Roberts Richard V.,
Friedrich Craig R.
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34496
Subject(s) - osseointegration , intramedullary rod , materials science , in vivo , fixation (population genetics) , biomedical engineering , implant , bone healing , surgery , biology , medicine , biochemistry , microbiology and biotechnology , gene
As total joint replacements increase annually, new strategies to attain solid bone‐implant fixation are needed to increase implant survivorship. This study evaluated two morphologies of titania nanotubes (TiNT) in in vitro experiments and an in vivo rodent model of intramedullary fixation, to simulate joint arthroplasty conditions. TiNT surfaces were prepared via an electrochemical etching process, resulting in two different TiNT morphologies, an aligned structure with nanotubes in parallel and a trabecular bone‐like structure. in vitro data showed bone marrow cell differentiation into osteoblasts as well as osteoblastic phenotypic behavior through 21 days. In vivo, both TiNT morphologies generated greater bone formation and bone‐implant contact than control at 12 weeks, as indicated by μCT analyses and histology, respectively. TiNT groups also exhibited greater strength of fixation compared to controls, when subjected to wire pull‐out testing. TiNT may be a promising surface modification for promoting osseointegration.