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Bone regeneration response in an experimental long bone defect orthotopically implanted with alginate‐pullulan‐glass‐ceramic composite scaffolds
Author(s) -
Popescu Radu A.,
Tăbăran Flaviu A.,
Bogdan Sidonia,
Fărcăṣanu Alexandru,
Purdoiu Robert,
Magyari Klara,
Vulpoi Adriana,
Dreancă Alexandra,
Sevastre Bogdan,
Simon Simion,
Papuc Ionel,
Baia Lucian
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34464
Subject(s) - pullulan , materials science , biomedical engineering , composite number , regeneration (biology) , bioactive glass , implant , bioceramic , ceramic , bone healing , chemistry , composite material , anatomy , surgery , medicine , biology , polysaccharide , biochemistry , microbiology and biotechnology
In the present study, scaffolds based on alginate‐pullulan‐bioactive glass‐ceramic with 0.5 and 1.5 mol % copper oxide were orthotopically implanted in experimental rat models to assess their ability to heal an induced bone defect. By implying magnetic resonance and imaging scans together with histological evaluation of the processed samples, a progressive healing of bone was observed within 5 weeks. Furthermore, as the regenerative process continued, new bone tissue was formed, enhancing the growth of irregular bone spicules around the scaffolds. A significantly higher amount of new bone was formed (37%) in the defect that received the composite with 1.5 mol % CuO (in glass‐ceramic matrix) content implant. Nevertheless, the bone regeneration obtained by scaffold with 0.5 mol % CuO implanted is comparable with the alginate‐pullulan‐β‐tricalcium phosphate/hydroxiapatite composite implant. The assessed amount of new bone formed was found to be between 29.75 and 37.15% for all the composition involved in the present study. During this process a regeneration process was shown when the alginate‐pullulan composite materials were involved, fact that indicate the great potential of these materials to be used in tissue engineering.