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Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model
Author(s) -
Barbosa Willams T.,
Almeida Katilayne V.,
Lima Gabriel G.,
Rodriguez Miguel A.,
Lia Fook Marcos V.,
GarcíaCarrodeguas Raul,
Amaro da Silva Junior Valdemiro,
Sousa Segundo Francisco A.,
Sá Marcelo J. C.
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34462
Subject(s) - materials science , radiodensity , biomedical engineering , implant , in vivo , osseointegration , calcium silicate , tibia , bone healing , wollastonite , calcium , biocompatibility , rabbit (cipher) , scaffold , anatomy , radiography , medicine , composite material , surgery , biology , raw material , ecology , statistics , microbiology and biotechnology , mathematics , metallurgy
Scaffolds are models designed to aid the interaction between cells and extracellular bone matrix, providing structural support for newly formed bone tissue. In this work, wollastonite with β‐TCP porous ceramic scaffolds was developed by the polymer sponge replication. Their microstructure, cell viability and bioactivity were tested. in vivo was performed to evaluate the use of a calcium silicate‐based implant in the repair of rabbit tibias. Holes were made in the both proximal and distal tibial metaphysis of each animal and filled with calcium silicate‐based implant, and in the left tibia, no implant were used, serving as control group. Animals underwent euthanasia after 30 and 60 days of study. The animals were submitted to clinical‐radiographic evaluations and their histology was analyzed by optical and scanning electron microscope. The studied calcium silicate implant provided biocompatibility and promoted bone formation, stimulating the process of bone repair in rabbits, features observed by gradual radiopacity shown in the radiographic evaluations.