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Composition control in biphasic silicate microspheres on stimulating new bone regeneration and repair of osteoporotic femoral bone defect
Author(s) -
GhamorAmegavi Edem P.,
Yang Xianyan,
Qiu Jiandi,
Xie Lijun,
Pan Zhijun,
Wang Juncheng,
Zhang Xiangfeng,
Ke Xiurong,
Zhao Tengfei,
Zhang Lei,
Gou Zhongru
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34396
Subject(s) - materials science , calcium silicate , biomaterial , chemical engineering , biomedical engineering , bioceramic , composite number , mesoporous material , nanotechnology , chemistry , composite material , medicine , biochemistry , engineering , catalysis
Application of bioactive materials as synthetic bone graft substitutes in regenerative medicine has seen great evolution over the past decades in treating challengeable bone defects. However, balancing the preparation conditions and biological performances of inorganic biomaterials remain a great challenge, especially when there is lack of biomaterial design on how to control component distribution and how pathological bone responds to the biomaterial stimulations and osteogenesis. Here, our objective is to develop yolk‐shell Ca‐silicate microspheres and to investigate the potential biological performances to overcome the limitations in repair of osteoporotic bone defects. The introduction of β‐calcium silicate (CaSiO 3 ) or mesoporous bioactive glass (MBG) into self‐curing β‐dicalcium silicate (Ca 2 SiO 4 ) cement shell to form spherical granules (CaSiO 3 @Ca 2 SiO 4 , MBG@Ca 2 SiO 4 ) was to retain the physicochemical property and/or microstructure of each component for optimizing bioactive ion release that could maximize osteostimulation in osteoporosis. We report a scalable shape‐controlled mild fabrication protocol to yield the yolk‐shell granules, endowing to different phases in yolk layer and interconnected macropore networks in the closely packed granule scaffolds. This unique heterostructure preparation is governed by coaxially aligned bilayer nozzle, inorganic powders and biocompatible binders. Extensive in vitro and in vivo evaluation showed that the CaSiO 3 @Ca 2 SiO 4 and MBG@Ca 2 SiO 4 granules exhibited many superior properties such as controllable ion release, improved biodegradation and enhanced osteogenic capability in comparison with the pure Ca 2 SiO 4 @Ca 2 SiO 4 , thereby opening new mild‐condition approach in fabricating osteogenesis‐tailored silicate biomaterials for bone regenerative medicine, especially for efficient reconstruction of challenging pathological bone defects.