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Effective delivery of mitomycin‐C and meloxicam by double‐layer electrospun membranes for the prevention of epidural adhesions
Author(s) -
Shi Rui,
Huang Yuelong,
Zhang Jingshuang,
Wu Chengai,
Gong Min,
Tian Wei,
Zhang Liqun
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34394
Subject(s) - meloxicam , adhesion , laminectomy , membrane , mitomycin c , nanofiber , chemistry , drug delivery , tissue adhesion , polycaprolactone , biomedical engineering , pharmacology , surgery , materials science , medicine , spinal cord , nanotechnology , biochemistry , psychiatry , polymer , organic chemistry
Epidural adhesion between the spinal dura and the surrounding fibrous tissue often occurs post‐laminectomy, resulting in clinical symptoms such as nerve compression and severe pain. In this study, we report a drug‐loaded double‐layered electrospun nanofiber membrane to prevent the occurrence of epidural adhesion. The nanofibers in both layers are made of a mixture of polycaprolactone (PCL) and chitosan (CS) but at different weight ratios. The bottom layer contacting to the spinal dura is loaded with meloxicam (MX) to prevent inflammation. The top layer that contacts to the fibrous tissue is doped with mitomycin‐C (MMC) to inhibit the synthesis of DNA and collagen. The two types of drugs are released from the double‐layered membrane within about 12 days. Meanwhile, the membrane can inhibit fibroblasts proliferation in vitro while show no cytotoxicity. In a rabbit laminectomy model, the double‐layered membrane can effectively prevent the epidural adhesion formation based on the adhesion scores, histological and biochemical evaluations. The combination release of MX and MMC can signally reduce the inflammation reaction and collagen I/III expression relative to the case with the membranes loaded with only either one type of the drugs. This approach offers new progresses in constructing dual drug delivery system and provides innovative barrier strategy in inhibiting epidural adhesion post‐laminectomy.

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