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Application of bacterial cellulose experimental dressings saturated with gentamycin for management of bone biofilm in vitro and ex vivo
Author(s) -
Junka Adam,
Bartoszewicz Marzenna,
Dziadas Mariusz,
Szymczyk Patrycja,
Dydak Karolina,
Żywicka Anna,
Owczarek Artur,
BilLula Iwona,
Czajkowska Joanna,
Fijałkowski Karol
Publication year - 2020
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34362
Subject(s) - bacterial cellulose , biofilm , microbiology and biotechnology , pseudomonas aeruginosa , antimicrobial , staphylococcus aureus , ex vivo , in vitro , in vivo , antibiotics , chemistry , cellulose , materials science , bacteria , biology , biochemistry , genetics
Bacterial cellulose is one of the most promising polymers of recent years. Herein, we present a possibility of BC application as a carrier of gentamycin antibiotic for the treatment and prevention of bone infections. We have shown that BC saturated with gentamycin significantly reduces the level of biofilm‐forming bone pathogens, namely Staphylococcus aureus and Pseudomonas aeruginosa , and displays very low cytotoxicity in vitro against osteoblast cell cultures. Another beneficial feature of our prototype dressing is prolonged release of gentamycin, which provides efficient protection from microbial contamination and subsequent infection. Moreover, it seems that bacterial cellulose (BC) alone without any antimicrobial added, may serve as a barrier by significantly hampering the ability of the pathogen to penetrate to the bone structure. Therefore, a gentamycin‐saturated BC dressing may be considered as a possible alternative for gentamycin collagen sponge broadly used in clinical setting. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:30–37, 2020.