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Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)‐ block ‐poly(oxirane)‐based nanofibrous electrospun polyester–ether–urethanes used as potential drug‐delivery system
Author(s) -
Pavelková Alena,
Kucharczyk Pavel,
Capáková Zdenka,
Peer Petra,
Pummerová Martina,
Zedník Jiří,
Vohlídal Jiří,
Sedlařík Vladimír
Publication year - 2019
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34331
Subject(s) - lactic acid , materials science , electrospinning , polyester , polymer chemistry , ether , chemical engineering , nanofiber , organic chemistry , polymer , composite material , chemistry , bacteria , genetics , engineering , biology
Poly(lactic acid)‐ block ‐poly(oxirane)s ( PLA ‐ b ‐ POE ) of various compositions were prepared using a one‐pot approach and then extended in a reaction with l ‐lysine diethyl ester diisocyanate, thereby forming polyester–ether–urethanes ( PEU ) with prolonged chains and units with increased degradability. The PEU s are processed by electrospinning to prepare degradable nanofibrous sheet materials with and without encapsulating the antibiotic Vancomycin ( VAC ). PLA block isomerism and POE blocks oligomeric content (1000 g/mol) affect the thermal properties, processability, nanofibrous sheet morphology, abiotic degradation, cytocompatibility, and encapsulated antibiotic release rate of prepared PEU s. Therefore, our findings provide an effective approach to tuning the functional properties of these advanced biocompatible materials. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2378–2387, 2019.