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Bone regeneration using three‐dimensional hexahedron channel structured BCP block in rabbit calvarial defects
Author(s) -
Pae HyungChul,
Kang JooHyun,
Cha JaeKook,
Lee JungSeok,
Paik JeongWon,
Jung UiWon,
Choi SeongHo
Publication year - 2019
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34317
Subject(s) - hexahedron , rabbit (cipher) , materials science , porosity , block (permutation group theory) , particle (ecology) , regeneration (biology) , bone mineral , biomedical engineering , computed tomography , volume (thermodynamics) , geometry , biology , mathematics , medicine , composite material , surgery , structural engineering , finite element method , pathology , engineering , physics , microbiology and biotechnology , ecology , osteoporosis , statistics , quantum mechanics
The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three‐dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in calvarium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deproteinized porcine bone mineral particle. Animals were euthanized at 2 ( n = 5 ) and 8 weeks ( n = 5 ). Outcome measures included micro‐computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro‐CT, BCP group showed the highest new bone volume with significant difference compared to control ( p = 0.008) at 8 weeks. Histomorphometrically, total augmented area of BCP group was the highest with significant difference compared to control ( p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2254–2262, 2019.