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Novel applications of nonwood cellulose for blood typing assays
Author(s) -
CasalsTerré Jasmina,
FarréLladós Josep,
Zuñiga Allinson.,
Roncero Maria Blanca,
Vidal Teresa
Publication year - 2019
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34245
Subject(s) - materials science , cellulose , microfluidics , biomedical engineering , polymer , capillary action , process engineering , refining (metallurgy) , computer science , composite material , nanotechnology , chemical engineering , medicine , engineering , metallurgy
Paper‐based microfluidics devices can create a new healthcare model. Cellulose is carbohydrate polymer biocompatible and hydrophilic. These characteristics enhance the development of user‐friendly diagnostic devices, but the link between paper manufacturing process and performance of the devices is still unclear. Previous studies focused on either commercial papers or lab papers from wood‐cellulose fibers, with different basis‐weight. This work introduces the effect of refining process and lab paper from nonwood‐cellulose fibers, focusing on sisal fibers to overcome the aforementioned challenge. Structural characteristics of paper, such as basis‐weight and degree of refining, are optimized and correlated with blood typing test resolution. Unrefined sisal paper of 50 g/m 2 and 100 g/m 2 basis‐weight exhibit a higher gray intensity level than refined paper, and also maximal capillary rise and a pore size suitable for blood grouping tests. Two different blood types were evaluated with results consistent with the traditional methods, testifying the usefulness of this methodology. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1533–1541, 2019.