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Sol–gel bioglasses in dental and periodontal regeneration: A systematic review
Author(s) -
Farano Vincenzo,
Maurin JeanChristophe,
Attik Nina,
Jackson Phil,
Grosgogeat Brigitte,
Gritsch Kerstin
Publication year - 2019
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34214
Subject(s) - dentistry , inclusion and exclusion criteria , mineralization (soil science) , regeneration (biology) , systematic review , population , biomedical engineering , materials science , biology , medicine , medline , pathology , microbiology and biotechnology , biochemistry , ecology , alternative medicine , environmental health , soil water
Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs) have attracted attention in tissue engineering, especially for mineralized tissue. The aim of this study is to review the current state of the art on the effects of BGs produced by sol–gel on cells for dental and periodontal regeneration. The study also discusses associated antibacterial properties. The research was performed by considering the Preferred Reporting Items for Systematic Reviews and the Meta‐Analyses (PRISMA) statement. The research ranged 5 years' window time (from January, 01, 2012, to August, 31, 2017) and the relevant studies were identified based on the inclusion/exclusion criteria. A total of 45 articles were selected from 244 initial returns, plus seven further articles coming from other sources were selected for the same purpose. From this systematic study, it is revealed that only 13 of the 52 articles have proved both the ability of BGs to differentiate dental cells at genetic level and their ability of triggering cell‐mediated mineralization, but only six of them showed, along with cells, the antibacterial properties of the glasses. This review shows that sol–gel BGs are not toxic, can sustain cell proliferation and differentiation at a genetic level, and can keep the bacterial population under control. Moreover, a standard methodology and an ideal material are suggested. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1210–1227, 2019.