Premium
Electrical stimulation: Complementary therapy to improve the performance of grafts in bone defects?
Author(s) -
Fonseca José Hyczy,
Bagne Leonardo,
Meneghetti Damaris Helena,
Santos Gláucia Maria Tech,
Esquisatto Marcelo Augusto Marretto,
Andrade Thiago Antônio Moretti,
Amaral Maria Esméria Corezola,
Felonato Maíra,
Caetano Guilherme Ferreira,
Santamaria Milton,
Mendonça Fernanda Aparecida Sampaio
Publication year - 2019
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34187
Subject(s) - calvaria , stimulation , bone grafting , grafting , biomedical engineering , materials science , bone healing , angiogenesis , medicine , surgery , chemistry , in vitro , composite material , biochemistry , polymer
The limitations of bone reconstruction techniques have stimulated the tissue engineering for the repair of large bone defects using osteoconductive materials and osteoinductive agents. This study evaluated the effects of low intensity electric current on the inorganic bovine graft in calvaria defects. Bone defects were performed with piezoelectric system in the calvaria of Wistar rats divided into four groups ( n = 24): (C) without grafting and without electrical stimulation; (E) with grafting; (MC) without grafting and submitted to electrical stimulation; (MC + E) with grafting and submitted to electrical stimulation. Inflammatory, angiogenic and osteogenic events during bone repair at the 10th, 30th, 60th, and 90th days were considered. Several inflammatory markers demonstrated the efficacy of grafting in reducing inflammation, particularly when subjected to electrical stimulation. Angiogenesis and collagen organization were more evident by electrical stimulation application on the grafts. Moreover, the osteogenic cell differentiation process indicated that the application of microcurrent on grafting modulated the homeostasis of bone remodeling. It is concluded that microcurrent favored the performance of grafts in calvarial rat model. Low‐intensity electrical current might improve the osteoconductive property of grafting in bone defects. Therefore, electrical current becomes an option as complementary therapy in clinical trials involving bone surgeries and injuries. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 924–932, 2019.