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Three‐dimensional printing of poly(glycerol sebacate fumarate) gadodiamide‐poly(ethylene glycol) diacrylate structures and characterization of mechanical properties for soft tissue applications
Author(s) -
Ravi Prashanth,
Wright Jamie,
Shiakolas Panos S.,
Welch Tré R.
Publication year - 2019
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34159
Subject(s) - materials science , composite material , ethylene glycol , ultimate tensile strength , polymer , dynamic mechanical analysis , elastic modulus , biomedical engineering , chemical engineering , medicine , engineering
Bioresorbable materials have been frequently used to three‐dimensional (3D) print biomedical structures. In this study, we developed a technique to 3D print poly(glycerol sebacate fumarate) gadodiamide (Rylar)‐poly(ethylene glycol) diacrylate (PEGDA) samples and investigated their mechanical and thermal properties as a function of (PS) and ultraviolet intensity (UVI). The Young's modulus ( E ), ultimate tensile strength (UTS), failure strain ( ɛ F ), and glass transition temperature ( T g ) showed strong correlation with PS and UVI. Results showed E to be between 1.31 and 3.12 MPa, UTS between 0.07 and 0.43 MPa, and ɛ F between 7 and 20% with brittle failure. The T g was observed to lie between −54.48 and −49.10 ° C without secondary/tertiary transitions. Dominant elastic behavior was observed from the dynamic mechanical testing viscoelastic data. Testing results were used to develop a regression predictive model for E as a function of PS and UVI. The model performance was evaluated experimentally with an average absolute error of 3.62%. The E and stress‐strain response of our 3D printed samples show agreement with published data for human tracheal cartilage, and the mechanical properties were comparable to other published soft polymeric scaffolds/patches. The E′ moduli were also similar to bovine articular cartilage. We have successfully demonstrated that Rylar, a novel bioresorbable radiopaque polymer, when blended with PEGDA can be 3D printed controllably for soft tissue applications such as airway obstructions. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 664–671, 2019.