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In vitro cell response and in vivo primary osteointegration of highly porous Ta‐Nb alloys as implant materials
Author(s) -
Liu Jue,
Zhou Xiongwen,
Wang Huifeng,
Yang Hailin,
Ruan Jianming
Publication year - 2019
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34149
Subject(s) - biocompatibility , materials science , osseointegration , in vivo , alloy , porosity , biomedical engineering , implant , in vitro , composite material , metallurgy , chemistry , medicine , biology , surgery , microbiology and biotechnology , biochemistry
By combining the biocompatibility of Ta and excellent performance of Nb, the β‐type Ta‐xNb ( x = 5, 10, and 15 wt %) alloys with three‐dimensional network structure was successfully fabricated. This work was designed to carry out the systematic study of in vitro / vivo biocompatibility of highly porous Ta‐Nb alloys. In the present study, the in vitro biological response was characterized by cell attachment, cytotoxicity test, and gene expression. Cells were well distributed on porous alloy surface and both bulk/porous Ta‐15Nb alloys showd a 0‐1 RGR level. Moreover, the upregulated gene expression may reveal an increase in bone regeneration. An assessment of primary osteogenic response in vivo was achieved by histological evaluation and pull‐out test. In vivo results demonstrated that the porous Ta‐15Nb alloy showed a higher pull‐out force than bulk Ta‐15Nb alloy and exhibited a more extensive contact between implants and bones after 12 weeks. Based on the present experiments, porous Ta‐Nb alloy scaffolds had a good biocompatibility and were promising for biomedical applications. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 573–581, 2019.