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Novel, cost‐effective, Cu‐doped calcium silicate nanoparticles for bone fracture intervention: Inherent bioactivity and in vivo performance
Author(s) -
Mabrouk Mostafa,
ElShebiney Shaimaa A.,
Kenawy Sayed H.,
ElBassyouni Gehan T.,
Hamzawy Esmat MA
Publication year - 2019
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34130
Subject(s) - materials science , nanoparticle , fourier transform infrared spectroscopy , simulated body fluid , bone healing , calcium silicate , calcium , scanning electron microscope , chemical engineering , silicate , bone tissue , transmission electron microscopy , composite material , biomedical engineering , nuclear chemistry , nanotechnology , metallurgy , chemistry , surgery , medicine , engineering
Copper (Cu)‐doped calcium silicate nanoparticles were synthesized by a wet precipitation method as economical bone fracture filler. The aim was to improve the overall physicochemical properties, bioactivity, and biological performance of the bone fracture filler prepared herein. The synthesized nanoparticles were evaluated using X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FT‐IR), and transmission electron microscopy (TEM). The bioactivity of the prepared nanoparticles was investigated after immersion in simulated body fluid (SBF) by means of inductively coupled plasma (ICP), SEM coupled with energy dispersive X‐rays (EDX), and FTIR. The size and bioactivity of the prepared nanoparticles after 15 days of immersion in SBF was dependent on the Cu concentrations. The fracture healing ability of the fabricated nanoparticles on adult aged male Wistar rats was enhanced by the presence of copper. All the obtained results are of high relevance for fabricating improved Cu‐doped calcium silicate nanoparticles (∼50 nm) as low cost bone fracture filler. In addition, the in vivo study presented complete healing of the tibiae bone with normal architecture of bone tissue specifically calcium silicate nanoparticles doped with 3% and 5% Cu. Hence, the presence of copper is a promising tactic for improving the biological properties of calcium silicate. Therefore, the designed nanoparticles have huge potential for the treatment of bone fractures. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 388–399, 2019.