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Wool‐derived keratin hydrogel enhances implant osseointegration in cancellous bone
Author(s) -
Duncan Warwick J.,
Greer Philippa F. C.,
Lee MinHo,
Loch Carolina,
Gay Jennifer H. A.
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34047
Subject(s) - osseointegration , materials science , resonance frequency analysis , implant , dentistry , keratin , biomedical engineering , cancellous bone , dental implant , endosseous implants , medicine , anatomy , surgery , pathology
Aim This study investigated whether a keratin hydrogel derived from wool enhances ossointegration of dental implants, using a cancellous bone model in sheep. Method Ten female sheep received one dental implant per hind leg in the distal femoral condyles. Test implants were coated with 1 mL of keratin hydrogel containing sulphonated keratin and hydroxyapatite; control implants remained uncoated; implants were not functionally loaded axially. Biomechanical stability was tested with resonance frequency analysis (RFA) at placement and euthanasia. Animals were sacrificed after 4 weeks and resin‐embedded histomorphometry performed. Findings : Bone appeared denser and more mature around the keratin‐treated test implants. Average % bone–implant contact was significantly increased for the test (58.1 ± 4.6 [SD]%) compared to control implants (34.4 ± 7.5%) ( p = 0.01). RFA values were lower for control (76.5 ± 4.2 ISQ) than test implants (80.4 ± 1.4) after 4 weeks ( p = 0.04). Conclusion the increase in osseointegration found in this model suggests that keratin hydrogel has the potential to enhance the successful osseointegration of dental implants placed into poor quality bone. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2447–2454, 2018.