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Effects of platelet‐rich plasma on biological activity and bone regeneration of brushite‐based calcium phosphate cement
Author(s) -
Hasan Md Lemon,
Taz Mirana,
Lee ByongTaek
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.34036
Subject(s) - brushite , cement , platelet rich plasma , simulated body fluid , materials science , apatite , bone cement , calcium , in vitro , in vivo , nucleation , regeneration (biology) , biomedical engineering , chemistry , biophysics , chemical engineering , platelet , mineralogy , composite material , biochemistry , microbiology and biotechnology , metallurgy , organic chemistry , medicine , engineering , biology
In this study, we focused on identifying the effects of platelet‐rich plasma (PRP) on bioactivity and bone ingrowths incorporated into brushite cement. We introduced PRP as a series of substitutions with an aqueous citrate‐ion solution, and the optimized cement with PRP showed no disintegration of the paste consistency. Incorporating PRP showed that the setting time decreased with the increasing of PRP ratios, although the compressive strength was not significantly changed. We evaluated in vitro degradation and bioactivity with the simulated body fluid test, and the result showed that adding PRP accelerated the carbonated apatite nucleation and markedly improved the surface reactivity of the cement. The in vitro studies demonstrated that incorporating PRP into the brushite cement improved cell adhesion and proliferation. The in vivo effects of PRP were faster degradation, improved tissue response in the early stage, and bone ingrowths. We demonstrated based on our results of this study, incorporation of PRP into brushite cement could be helpful for improving biological activity of the cement as well as bone regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2316–2326, 2018.