Premium
An effective thermal therapy against cancer using an E‐jet 3D‐printing method to prepare implantable magnetocaloric mats
Author(s) -
Yang Yikun,
Tong Chunyi,
Zhong Juchang,
Huang Ruiying,
Tan Weihong,
Tan Zhikai
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33992
Subject(s) - magnetic refrigeration , hyperthermia , materials science , hyperthermia treatment , magnetic hyperthermia , in vivo , biomedical engineering , substrate (aquarium) , magnetic nanoparticles , nanoparticle , nanotechnology , magnetic field , medicine , magnetization , biology , ecology , physics , microbiology and biotechnology , quantum mechanics
Magnetic hyperthermia has been rapidly developed as a potential cancer treatment in recent years. Artificially induced hyperthermia close to a tumor can raise the temperature to 45°C causing tumor cell death. Herein, we introduce a novel method for rapid preparation of anti‐cancer magnetocaloric PCL/Fe 3 O 4 mats capable of high‐performance hyperthermia using E‐jet 3D printing technology. Our 3D printed mats not only maintained the heating efficiency of traditional techniques for magnetic hyperthermia but also prolonged the effective therapy in vivo . When Fe 3 O 4 nanoparticles (NPs) were used in mats at a concentration of 6 mmol/L, 0.07 g PCL/Fe 3 O 4 mats were able to increase the temperature peripherally to 45°C under an alternating magnetic field (AMF) within 45 min. Moreover, the reproducibility experiment indicated that the maximum temperature was achieved following repeated heating and cooling cycles. Cell toxicity tests showed a high cell death rate during one treatment cycle. In vivo experiments indicated clear signs of tumor growth inhibitory and prolonged survival time of tumor‐bearing mice after 4 weeks of treatment. The present magnetic mats may be a potential candidate for a novel heat‐generating substrate for localized hyperthermia cancer therapy. Furthermore, the main advantage of such implantable magnetic mats is the local and precise delivery of Fe 3 O 4 NPs, ideal for the hyperthermia treatment of easily accessible tumors. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1827–1841, 2018.