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Development of high strength siloxane poly(urethane‐urea) elastomers based on linked macrodiols for heart valve application
Author(s) -
Dandeniyage Loshini S.,
Gunatillake Pathiraja A.,
Adhikari Raju,
Bown Mark,
Shanks Robert,
Adhikari Benu
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33970
Subject(s) - isophorone diisocyanate , materials science , hexamethylene diisocyanate , ultimate tensile strength , polyurethane , siloxane , elastomer , tear resistance , composite material , polymer chemistry , polymer
Mixed macrodiol based siloxane poly(urethane‐urea)s (SiPUU) having number average molecular weights in the range 87–129 kDa/mol were synthesized to give elastomers with high tensile and tear strengths required to fabricate artificial heart valves. Polar functional groups were introduced into the soft segment to improve the poor segmental compatibility of siloxane polyurethanes. This was achieved by linking α,ω‐bis(6‐hydroxyethoxypropyl) poly(dimethylsiloxane) (PDMS) or poly(hexamethylene oxide) (PHMO) macrodiols with either 4,4′‐methylenediphenyl diisocyanate (MDI), hexamethylene diisocyanate (HDI) or isophorone diisocyanate (IPDI) prior to polyurethane synthesis. The hard segment was composed of MDI, and a 1:1 mixture of 1,3‐bis(4‐hydroxybutyl)‐1,1,3,3‐tetramethyldisiloxane and 1,2‐ethylene diamine. We report the effect of urethane linkers in soft segments on properties of the SiPUU. PHMO linked with either MDI or IPDI produced SiPUU with the highest tensile and tear strengths. Linking PDMS hardly affected the tensile strength; however, the tear strength was improved. The stress‐strain curves showed no plastic deformation region typically observed for conventional polyurethanes indicating good creep resistance. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1712–1720, 2018.