Premium
When epigenetics meets bioengineering—A material characteristics and surface topography perspective
Author(s) -
Larsson Lena,
Pilipchuk Sophia P.,
Giannobile William V.,
Castilho Rogerio M.
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33953
Subject(s) - epigenetics , regeneration (biology) , chromatin , regenerative medicine , perspective (graphical) , gene expression , biology , microbiology and biotechnology , tissue engineering , chromatin remodeling , epigenesis , computational biology , gene , neuroscience , dna methylation , genetics , stem cell , computer science , artificial intelligence
The field of tissue engineering and regenerative medicine (TE/RM) involves regeneration of tissues and organs using implantable biomaterials. The term epigenetics refers to changes in gene expression that are not encoded in the DNA sequence, leading to remodeling of the chromatin and activation or inactivation of gene expression. Recently, studies have demonstrated that these modifications are influenced not only by biological cues but also by mechanical and topographical signals. This review highlights the current knowledge on emerging approaches in TE/RM with a focus on the effect of materials and topography on the epigenetic expression pattern in cells with potential impacts on modulating regenerative biology. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2065–2071, 2018.