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Methacrylate‐based root canal sealer containing chlorexidine and α‐tricalcium phosphate
Author(s) -
Collares Fabrício Mezzomo,
Leitune Vicente Castelo Branco,
Portella Fernando Freitas,
Santos Paula Dapper,
Balbinot Gabriela de Souza,
dos Santos Luís Alberto,
Parolo Clarissa Cavalcanti Fatturi,
Samuel Susana Maria Werner
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33946
Subject(s) - radiodensity , root canal , enterococcus faecalis , methacrylate , chlorhexidine , nuclear chemistry , dentistry , materials science , phosphate , chemistry , composite material , copolymer , surgery , medicine , organic chemistry , polymer , biochemistry , radiography , escherichia coli , gene
The aim of this study was to develop and to characterize a methacrylate‐based root canal sealer containing chlorhexidine (CHX) and α‐tricalcium phosphate (α‐TCP). Experimental dual cure methacrylate‐based sealer was produced containing 0, 2.5, or 5 wt% of CHX and 0, 25, or 50 wt% of α‐TCP. Experimental sealers were evaluated based on flow, film thickness, radiopacity, degree of conversion (DC), degradation in water, pH and antibacterial activity. Flow ranged from 15.09 ± 0.11 to 17.47 ± 0.42 mm. All groups presented mean film thickness lower than 50 µm and had radiopacity equivalent to 3 mmAl. DC was higher than 60% for all compositions. The weight loss (WL) ranged 0.12–3.47%. The groups containing 5% of CHX presented the highest WL and the lower pH values after 28 days of water immersion. All chlorexidine‐compositions exhibited antibacterial efficacy against Enterococcus faecalis on direct contact and agar diffusion tests. CHX and α‐TCP addition at an experimental methacrylate‐based root canal sealer influenced the physicochemical properties and provided antibacterial properties. The incorporation of CHX and α‐TCP could be an alternative to antibacterial sealers with potential to improve periapical healing in endodontic treatments. © 2017 Wiley Periodicals, Inc. J Biomater Res Part B: 106B: 1439–1443, 2018.