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Biocompatibility of four common orthopedic biomaterials following neuroelectromyostimulation: An in‐vivo study
Author(s) -
Lecocq Mathieu,
Felix MarieSolenne,
Bernard Cécile,
Linares JeanMarc,
ChavesJacob Julien,
Decherchi Patrick,
Dousset Erick
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33927
Subject(s) - biocompatibility , implant , titanium alloy , orthopedic surgery , titanium , materials science , prosthesis , biomedical engineering , in vivo , arthroplasty , medicine , dentistry , surgery , alloy , composite material , metallurgy , biology , microbiology and biotechnology
Despite the worldwide high prevalence of total joint arthroplasty (TJA), life expectancy of prosthesis remains limited by mechanical and chemical constraint which promote wear debris production, surrounding tissues damage and finally prosthesis loosening. Such results could be amplified by neuro‐myoelectrostimulation (NMES; widely used to reduce neuromuscular deficits observed following TJA surgery). It was previously described in an in vivo experiment that interactions between NMES and Ti6Al4V implant are deleterious for both implant and surrounding muscles. The purpose of the present study was to compare the biocompatibility of four common orthopedic biomaterials, two metallic (Ti6Al4V, CrCo) and two nonmetallic (PEEK, Al 2 O 3 ) alloys, fixed on rat tibial crest in which the surrounding muscles were electrostimulated. Muscle cell death rate was not found significantly increased, with or without electrical stimulation for nonmetallic implants. Contrary to Ti6Al4V alloy, the CrCo implant did not induce destruction of the surrounding muscle. However, cell viability decreased for both metallic alloys when NMES was applied but within a greater significant extent for Ti6Al4V implant. Otherwise, when NMES was applied, implant‐to‐bone adhesion significantly decreased for Ti6Al4V while no significant difference was found for PEEK, Al 2 O 3 , and CrCo. Statistical analyses reveal also a lesser adhesion strength for Ti6Al4V compared with CrCo when NMES was applied. Selecting the most suitable material in term of biocompatibility remains a major concern and non‐metallic materials seems to be more appropriated in regard to electrical currents used for post TJA care. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1156–1164, 2018.