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Antibacterial efficacy of poly(vinyl alcohol) composite nanofibers embedded with silver‐anchored silica nanoparticles
Author(s) -
Jatoi Abdul Wahab,
Jo Yun Kee,
Lee Hoik,
Oh SeongGeun,
Hwang Dong Soo,
Khatri Zeeshan,
Cha Hyung Joon,
Kim Ick Soo
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33925
Subject(s) - vinyl alcohol , nanofiber , silver nanoparticle , materials science , electrospinning , composite number , antibacterial activity , nanoparticle , nanotechnology , chemical engineering , composite material , bacteria , polymer , biology , engineering , genetics
Silver has been widely used as an effective antibacterial agent especially for treating burns and wounds. However, release of silver from materials often arouse side effects due to toxicity of silver towards mammalian cells. A rgyria and argyrosis are well known problems of acute toxicity of silver towards human body. Immobilization of silver is an effective approach to reduce silver release. Herein, we present poly(vinyl alcohol) (PVA) composite nanofibers embedded with silver‐anchored silica nanoparticles (SSNs) as a novel antibacterial material. Silver nanoparticles anchored on silica nanoparticles were prepared and incorporated into PVA nanofibers to fabricate silver‐silica embedded PVA nanofibers (SSN‐PVA) by electrospinning. Incorporation of SSNs into PVA was confirmed by TEM and SEM results revealed regular nanofibers whose diameter increased with successive addition of SSNs. The SSN‐PVA nanofibers showed significant antibacterial efficacy against both Gram‐negative and Gram‐positive bacteria. Our research results demonstrated SSN‐embedded polymeric nanofibers can open up a promising prospect for the prevention of bacterial infection in diverse biomedical fields including wound dressing. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1121–1128, 2018.