Premium
Hyperthermia effect and antibacterial efficacy of Fe 3+ /Co 2+ co‐substitutions in β‐Ca 3 (PO 4 ) 2 for bone cancer and defect therapy
Author(s) -
Singh Ram Kishore,
Srivastava M.,
Prasad N. K.,
Shetty P. H.,
Kannan S.
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33921
Subject(s) - biocompatibility , hyperthermia , cytotoxicity , cobalt , chemistry , nuclear chemistry , materials science , in vitro , inorganic chemistry , biochemistry , medicine , organic chemistry
The combined effect of cobalt and iron substitutions in β ‐Ca 3 (PO 4 ) 2 as a potent material for application in hyperthermia and as a bone substitute is presented. Structural analysis reveals the preferential accommodation of Co 2+ and Fe 3+ at the Ca 2+ (5) sites of β ‐Ca 3 (PO 4 ) 2 until the limit of ∼10 mol % and, thereafter, prefer Ca 2+ (4) lattice sites. Occupancy of both the Co 2+ and Fe 3+ ions induces a significant contraction of the β ‐Ca 3 (PO 4 ) 2 unit cell. The Co 2+ /Fe 3+ co‐substitutions in β ‐Ca 3 (PO 4 ) 2 display magnetic characteristics that enhances hyperthermia effect. In addition, the presence of Co 2+ in β ‐Ca 3 (PO 4 ) 2 enunciates pronounced antibacterial efficacy against tested microorganisms. Nevertheless, the enhanced level of Co 2+ in β ‐Ca 3 (PO 4 ) 2 results to induce significant toxicity. The biocompatibility of the synthesized thermoseeds is verified from the hemolytic tests and cytotoxicity test performed on human sarcoma cell line MG‐63. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1317–1328, 2018.