Premium
Enhancement of plasma protein adsorption and osteogenesis of hMSCs by functionalized siloxane coatings for titanium implants
Author(s) -
MartínezIbáñez Maria,
Murthy N. Sanjeeva,
Mao Yong,
Suay Julio,
Gurruchaga Marilo,
Goñi Isabel,
Kohn Joachim
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33889
Subject(s) - siloxane , titanium , adsorption , materials science , protein adsorption , plasma , biomedical engineering , chemical engineering , chemistry , composite material , metallurgy , polymer , organic chemistry , medicine , engineering , physics , quantum mechanics
A series of sol–gel derived silicon based coatings were developed to improve the osseointegration of commercial titanium dental implants. The osseointegration starts with a positive interaction between the implant surface and surrounding tissues, which is facilitated by the adsorption of plasma proteins onto the biomaterial surface immediately after implantation. It is likely that the enhancement of protein adsorption to titanium implants leads to a better implant/tissue integration. In addition, silica based biomaterials have been shown to promote osteoblast differentiation. To improve the protein adsorption and the osteogenesis, methyltrimethoxysilane (MTMOS), tetraethoxysilane (TEOS), 3‐glycidoxypropyltrimethoxysilane (GPTMS), and gelatin were selected to coat titanium surfaces. Compared with non‐coated titanium, the functionalized coatings enhanced the adsorption of adhesive proteins such as fibronectin and collagen. The Si release was successfully modulated by the control of the chemical composition of the coating, showing a higher dissolution rate with the gelatin and GPTMS incorporation. While the roughness of commercial implants seemed to promote the adhesion of mesenchymal stem cells (MSC), the osteogenic differentiation was greater on surfaces with Si‐coatings. In this study, an improved osteogenic surface has been achieved by using the siloxane‐gelatin coatings and such coatings can be used in dental implants to promote osseointegration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1138–1147, 2018.