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Chitosan coatings with enhanced biostability in vivo
Author(s) -
Gallyamov Marat O.,
Chaschin Ivan S.,
Bulat Matvey V.,
Bakuleva Natalia P.,
Badun Gennadii A.,
Chernysheva Maria G.,
Kiselyova Olga I.,
Khokhlov Alexei R.
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33852
Subject(s) - chitosan , materials science , glutaraldehyde , in vivo , biodegradation , pericardium , coating , connective tissue , chemical engineering , biomedical engineering , composite material , chromatography , surgery , chemistry , organic chemistry , pathology , medicine , microbiology and biotechnology , engineering , biology
In this article, we study the stability of chitosan coatings applied on glutaraldehyde‐stabilized bovine pericardium when exposed to biodegradation in vivo in the course of model subcutaneous tests on rats. The coatings were deposited from carbonic acid solutions, that is, H 2 O saturated with CO 2 at high pressure. Histological sections of treated pericardium samples demonstrated that the structure of pericardial connective tissues was not significantly altered by the coating application method. It was revealed that the dynamics of biodegradation depended on the total mass of chitosan applied as well as on the DDA of chitosan used. As long as the amount of chitosan did not exceed a certain threshold limit, no detectable degradation occurred within the time of the tests (12 weeks for the rat model). For higher chitosan amounts, we detected a ∼20% reduction of the mass after the in vivo exposition. The presumed mechanism of such behavior is discussed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 270–277, 2018.