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3D bioprinting and its in vivo applications
Author(s) -
Hong Nhayoung,
Yang GiHoon,
Lee JaeHwan,
Kim GeunHyung
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33826
Subject(s) - biomanufacturing , 3d bioprinting , 3d printing , nanotechnology , biofabrication , in vivo , computer science , 3d printed , tissue engineering , biomedical engineering , engineering , materials science , biology , mechanical engineering , microbiology and biotechnology
The purpose of 3D bioprinting technology is to design and create functional 3D tissues or organs in situ for in vivo applications. 3D cell‐printing, or additive biomanufacturing, allows the selection of biomaterials and cells (bioink), and the fabrication of cell‐laden structures in high resolution. 3D cell‐printed structures have also been used for applications such as research models, drug delivery and discovery, and toxicology. Recently, numerous attempts have been made to fabricate tissues and organs by using various 3D printing techniques. However, challenges such as vascularization are yet to be solved. This article reviews the most commonly used 3D cell‐printing techniques with their advantages and drawbacks. Furthermore, up‐to‐date achievements of 3D bioprinting in in vivo applications are introduced, and prospects for the future of 3D cell‐printing technology are discussed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 444–459, 2018.