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Limitation of the antibiotic‐eluting bone graft substitute: An example of gentamycin‐impregnated calcium sulfate
Author(s) -
Wu ChangChin,
Huang YangKai,
Chang WeiJen,
Wu YunChing,
Wang ChenChie,
Yang KaiChiang
Publication year - 2018
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33815
Subject(s) - calcium , materials science , biomedical engineering , sulfate , in vivo , dentistry , medicine , metallurgy , biology , microbiology and biotechnology
Patients with inadequate volume of alveolar processes or bone defects commonly require graft substitutes in oral, maxillofacial or orthopedic surgery. Ridge augmentation and reconstruction of facial bony defects with bone graft materials achieve better outcomes in functional and aesthetic rehabilitation. The injectable calcium sulfate filler is used widely in intra‐operative applications. Calcium sulfate bone filler has been shown to upregulate bone formation‐related mRNA genes in vitro and improve osseointegration in vivo . In addition, the bone graft substitute can be used as a drug delivery system for antibiotics to treat or prevent infections based on the clinical experiences. However, the influences of antibiotics addition on the calcium sulfate are not fully understood. In this study, calcium sulfate impregnated with gentamycin in different weight ratios was characterized. The results showed that gentamycin prolonged the hydration process and extended initial/final setting times of calcium sulfate. The addition of gentamycin slowed the conversion from calcium sulfate hemihydrate to dihydrate and changed the crystalline phase and microstructure. Higher amounts of gentamycin added resulted in faster degradation and lower mechanical strength of calcium sulfate. This study reveals that the extended setting time, decreased compressive strength, and the accelerated degradation of the gentamycin‐impregnated calcium sulfate bone graft substitutes should be considered during intra‐operative applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 80–87, 2018.