Premium
Hemocompatibility and oxygenation performance of polysulfone membranes grafted with polyethylene glycol and heparin by plasma‐induced surface modification
Author(s) -
Wang Weiping,
Zheng Zhi,
Huang Xin,
Fan Wenling,
Yu Wenkui,
Zhang Zhibing,
Li Lei,
Mao Chun
Publication year - 2017
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33709
Subject(s) - polysulfone , membrane , polyethylene glycol , surface modification , contact angle , materials science , peg ratio , protein adsorption , permeation , fourier transform infrared spectroscopy , chemical engineering , polymer chemistry , chromatography , chemistry , polymer , nuclear chemistry , composite material , organic chemistry , biochemistry , finance , engineering , economics
Polyethylene glycol (PEG) and heparin (Hep) were grafted onto polysulfone (PSF) membrane by plasma‐induced surface modification to prepare PSF–PEG–Hep membranes used for artificial lung. The effects of plasma treatment parameters, including power, gas type, gas flow rate, and treatment time, were investigated, and different PEG chains were bonded covalently onto the surface in the postplasma grafting process. Membrane surfaces were characterized by water contact angle, PEG grafting degree, attenuated total reflectance‐Fourier transform infrared spectroscopy, ultraviolet–visible spectrophotometry, X‐ray photoelectron spectroscopy, critical water permeability pressure, and scanning electron microscopy. Protein adsorption, platelet adhesion, and coagulation tests showed significant improvement in the hemocompatibility of PSF–PEG–Hep membranes compared to pristine PSF membrane. Gas exchange tests through PSF–PEG6000–Hep membrane showed that when the flow rate of porcine blood reached 5.0 L/min, the permeation fluxes of O 2 and CO 2 reached 192.6 and 166.9 mL/min, respectively, which were close to the gas exchange capacity of a commercial membrane oxygenator. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1737–1746, 2017.